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VP, HEAD OF DRUG DISCOVERY

Position Summary

Differentiated Therapeutics, a discovery-stage biotech company focusing on the discovery and development of disease-modifying therapies by harnessing natural protein homeostasis processes, is seeking an exceptional leader to head our drug discovery efforts. This pivotal role is dedicated to driving the advancement of our degrader portfolio through pre-clinical development, employing cutting-edge technologies and innovative strategies to tackle diseases with significant treatment gaps.

Responsibilities

  • Strategic Leadership: Direct the progression of the degrader drug discovery programs in our portfolio, ensuring alignment with our mission to lead in the field of targeted protein degradation.

  • Team Management: Build and lead a team of chemists, biologists, and simulation experts, fostering a collaborative environment that encourages innovation and high standards in scientific research.

  • Innovation in Degrader Design: Direct the development of novel bivalent molecules and molecular glues. Oversee the screening, hit identification, and lead optimization stages specific to degrader technologies.

  • Collaboration and Networking: Enhance external collaborations with pharmacology, toxicology, and clinical teams and maintain robust external partnerships with academic leaders, biotech firms, and CROs.

  • Regulatory and Compliance Insight: Ensure that all aspects of the drug discovery process meet global regulatory standards and ethical practices, particularly in early-stage preclinical development.

  • Scientific Representation: Act as a key scientific spokesperson for the company in forums focusing on protein degradation and broader therapeutic areas, enhancing the company's scientific stature and visibility.

 

Qualifications

  • PhD in Chemistry, Biochemistry, Pharmacology, or a related field, with a strong focus on medicinal chemistry.

  • Minimum of 12 years of experience in pharmaceutical or biotechnology drug discovery, including significant work with targeted protein degradation.

  • Demonstrated success in leading degrader drug discovery projects from concept through to IND filing.

  • Deep expertise in the mechanisms of targeted protein degradation and associated technologies such as E3 ligase modulators.

  • Exceptional leadership and organizational skills, with a proven ability to inspire and manage a high-performing team.

  • Strategic and analytical thinker with robust problem-solving skills and the ability to adapt to a rapidly evolving landscape.

 

We Offer

  • Competitive compensation package, including salary, benefits, and equity incentives.

  • A dynamic work environment in a rapidly growing organization.

  • Opportunities for significant career development and contributions to major advancements in healthcare.

  • The chance to impact patient care profoundly through innovative therapeutic approaches.

Please send your CV and cover letter to work@dxtherapeutics.com if you are interested in this opportunity.

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